Agago District is bordered by Kitgum District to the north, Kotido District to the northeast, Abim District to the east, Otuke District, to the south, and Pader District to the west. Agago, the location of the district headquarters is located approximately 80 kilometres (50 mi), by road, southeast of Kitgum, the nearest large town. This location lies approximately 370 kilometres (230 mi), by road, north of Kampala, the capital of Uganda, and the largest city in that country.

Agago District is one of the newest districts in Uganda. It was established by Act of Parliament and began functioning on 01 July 2010. Prior to that date, it was part of Pader District. The district is part of the Acholi sub-region, together with:
Amuru District
Gulu District
Kitgum District
Lamwo District
Nwoya District
Pader District

Secondary Schools in Agago District
1 Adilang Secondary School Agago Secondary +256-7826565
2 Agago High School Agago Secondary +256-775309088
3 Ajalia Secondary School Agago Secondary +256-392960355
4 Akwang Secondary School Agago Secondary +256-782267036
5 Barbra Rivera Memorial Secondary School Agago Secondary +256-779705302
6 Lapono Seed Secondary School Agago Secondary +256-782328630
7 Lira Palwo Secondary School Agago Secondary +256-392881103
8 Omot Seed Secondary School Agago Secondary +256-
9 Patongo Homebase Secondary School Agago Secondary +256-774140906
10 Patongo Seed Secondary School Agago Secondary +256-782563111
11 St. Charles Lwanga’s College Agago Secondary +256-772855930
12 St. Francis High School Kalongo Agago Secondary +256-
13 Wol Secondary School Agago Secondary +256-781835116